In the Last days of Ayub era, unstable political environment was paving the way for the Bengali nationalism that eventually led to the creation of Bangladesh. Particularly the policies adopted by Ayub Khan after usurpation of power were the sole reason for it. Basic democracy system was one of such policies considered to be the root cause of the widespread corruption. Ayub relied on it to perhaps stay in power for life.

The political atmosphere in Pakistan became more volatile after the Indo-Pak War of 1965. After war a "historic pact" was signed between Pakistan and India at Tashkent. The people of Pakistan considered the pact to be a sell-out and became anti-Ayub. Analysing the pulse of masses the then Foreign Minister Zulfiqar Ali Bhutto delivered a very highly emotional speech, criticizing and opposing the Tashkent declaration and left the podium dramatically. On his return to Pakistan, he resigned from his Ministership in protest and entered active politics by forming Pakistan People's Party (PPP) and launched anti Ayub movements.

As East Pakistan was totally cut-off from West Pakistan in the 1965-war, Sheikh Mujeeb Ur Rehman declared his famous six-point seeking autonomy in economy, defence and foreign trade for East Pakistan to become self-reliant and self-sufficient political unit. He also offered to hold talks with the Ayub Government in this regard.

Ayub Khan tried his best to wind up the situation by holding the round table conference, but everything was turning against him as some high-ranking members of armed forces were hatching conspiracies by simultaneously backing the politicians against Ayub Khan. These forces were so much intensifying day by day that Ayub Khan was attacked with "pulmonary embolism" and became physically and politically handicapped hence he resigned in 1966 marking an end to his politics and government.